vaginal microbiome Research
I completed my PhD in the in the Ravel lab at the University of Maryland / Institute for Genome Science (IGS) in Baltimore, MD, USA. where I identified host-microbial interactions in the human vaginal microbiome. I applied machine learning algorithms to prioritize miRNAs for further experimentation and identified a key host response in protection against a sexually transmitted infection. I am currently preparing a manuscript. Stay tuned!
Jacques and I published a review article in the Journal of Physiology:
Smith, S. B. and Ravel, J. (2017), The vaginal microbiota, host defence and reproductive physiology. J Physiol, 595: 451–463. doi:10.1113/JP271694
pan Respiratory Viral & bacterial projects
Along with collaborators at GlaxoSmithKline Pharmaceuticals and Drexel University, I computationally discovered common host responses across seven and two different respiratory viral and bacterial pathogens, respectively:
Smith SB, Dampier W, Tozeren A, Brown JR, Magid-Slav M (2012) Identification of Common Biological Pathways and Drug Targets Across Multiple Respiratory Viruses Based on Human Host Gene Expression Analysis PLoS ONE 7(3): e33174. doi:10.1371/journal.pone.0033174
Smith SB, Magid-Slav M, Brown JR (2013) Host Response to Respiratory Bacterial Pathogens as Identified by Integrated Analysis of Human Gene Expression Data. PLoS ONE 8(9): e75607. doi:10.1371/journal.pone.0075607
A Showcase of other projects
I have a myriad of other projects in which I designed experiments and applied computational methods:
- Designed & Implemented MySQL databases to manage major projects.
- Identifyed Novel miRNA in Arabidopsis Thaliana
- Safety Assessment Study at AstraZeneca Pharmaceuticals
- Design & Implementation of a Brain-Computer Interface
- Image Recognition using a Neural Network
- Research Development Study at Lyophilization Technology, Incorporated